Major Lancet review finds most IVF add-ons provide no clear benefit to fertility patients

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Imagine paying lakhs for hope.

And then being told… most of it was optional theatre.

That's the gut-punch from a major new Lancet review on IVF.

Researchers looked at 10 of the most popular IVF "add-ons" — the extra injections, tests, glues and scratches clinics tack on to boost your odds.

The verdict? 🤯

7 out of 10 showed no clear benefit.


💸 The add-on economy nobody wants to talk about

Over the last decade, IVF clinics quietly built a second business on top of IVF.

Extra scans. Extra injections. Extra "science-y" sounding tech.

And patients said yes — because when you're chasing a baby, you say yes to everything.

In the UK, Australia and New Zealand, over 70% of IVF patients report using at least one add-on.

India? Roughly 3.5 lakh IVF cycles a year, mostly paid out of pocket.

  • 🏥 Private hospital cycle: ~₹2.3 lakh

  • 🏛️ Public hospital cycle: ~₹1.1 lakh

  • 🔁 And most couples need multiple cycles

Now stack add-ons on top of that. The bill spirals fast.


🔬 What the Lancet team actually did

They pulled 157 trials.

Threw out 72 for being too sketchy to trust.

Analysed the remaining 85 with proper rigour.

Here's the scoreboard 👇

❌ No clear benefit / weak evidence:

  • Acupuncture

  • Corticosteroids

  • Endometrial receptivity testing

  • Intralipid infusion

  • PRP injections (ovaries/uterus)

  • Pre-implantation genetic testing (PGT-A)

  • (and one more in the "inconclusive" pile)

🟡 Weak positive signals only:

  • EmbryoGlue — maybe better pregnancy odds

  • Endometrial scratching — maybe a small lift

  • PICSI sperm selection — maybe fewer miscarriages

Maybe. Maybe. Maybe. Not exactly the certainty a ₹2 lakh bill deserves.


⚡ The quote that should worry every clinic

Dr Sarah Lensen from the University of Melbourne, who co-led the review, didn't sugarcoat it.

She said unproven add-ons create false hope, drain savings, and put patients through extra medical procedures during one of the most emotional periods of their lives.

Misinformation, she added, is everywhere — clinic websites, Instagram fertility influencers, WhatsApp groups — usually overstating benefits and hiding the costs.


🧠 The real takeaway

IVF itself still works. A single cycle gives roughly 30–40% chance of a baby globally.

But the glittery extras sold alongside it? Mostly unproven.

The researchers even built an independent website with honest, evidence-based info on every add-on. In trials, patients who used it understood their choices far better than those Googling at midnight.

Because in fertility care, the most powerful add-on isn't a serum or a scratch.

It's the truth.

That's all for now!